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The published preclinical literature uses weight-adjusted rodent dosing that doesn't translate cleanly to fixed human protocols, so researchers extrapolate

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Patanwala I, King MJ, Barrett DA, Rose J, Jackson R, Hudson M, Philo M, Dainty JR, Wright AJA, Finglas PM et al

When NNMT activity is elevated as documented in obese adipose tissue, several cancer types, and aged skeletal muscle intracellular NAD+ availability decreases, SAM availability decreases, and downstream sirtuin activity (particularly SIRT1 and SIRT3) is reduced