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EV isolation and quantification Media was harvested from U251 cells 2 h post hypoxic or control normoxic incubation and was pre-cleared by centrifugation twice at 3000 g for 15 min

Glutathione interrupts this process through multiple mechanisms: it inhibits the enzyme tyrosinase, which catalyzes melanin production

Ye F, Zhou F, Bedolla RG, Jones T, Lei X et al

10 AlipourM.VerdomB.AkhlaghdoustM.SafariS.ZaliA

*Correspondence: Juan Carlos Alvarado [email protected] Specialty section: This article was submitted to Cellular Neuropathology, a section of the journal Frontiers in Cellular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Rama-Devi, S