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Medical Adviser to the ME Association, Member of the 2018-2021 NICE guideline on ME/CFS committee, Member of the 2002 Chief Medical Officer's Working Group on ME/CFS

while some patients report subtle shifts in energy within a few weeks, it typically takes 2 to 3 months of daily supplementation to sufficiently replenish deep intracellular nutrient deficits and observe meaningful changes in baseline fatigue

I mention the bottom as I imagine it would hurt less

Am J Pathol (2011) 179(1):289301

It is completely tolerable and fades within minutes

The medications most commonly associated with B12 deficiencies include metformin (diabetes), antacids, anti-ulcers, blood pressure, cholesterol meds, and birth control pills (12, 13)