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Both processes also occur in vivo (Smith and Morgan, 1981)

Bioinformatics analyses of the transcriptome reveal ube3a-dependent effects on mitochondrial-related pathways

Consequently, HIF-1 depletion in mouse embryo fibroblasts results in excessive ROS, reduced glycolytic metabolism, and cell death

These reactions are vital for maintaining cellular homeostasis and epigenetic regulation

ROS sources and sinks in mitochondria, peroxisomes and the ER The powerful oxidant dioxygen or molecular oxygen (O 2 ) exhibits a particular chemistry 40,41 , also termed the molecular O 2 paradox 42