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We speculate that abnormal iron metabolism and gut microbiota dysbiosis can promote each other and play a synergistic role in promoting ferroptosis of chondrocytes

This suggests that aging and ferroptosis may form a vicious cycle that mutually reinforces each other, although the underlying mechanisms require further investigation

B.JacobS

Imaging modalities to visualize ferroptosis (for example, novel MRI contrast agents or PET tracers for iron-driven lipid peroxidation) remain in early development

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