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Both are administered intranasally, simplifying the protocol

doi: 10.1371/journal.pone.0191866 7 LeeBEChoiBYHongDKKimJHLeeSHKhoARet al

10.1038/nature09944 11 BckhedF.LeyR

The key difference is that retatrutide provides triple agonism (GLP-1 + GIP + glucagon) while semaglutide provides only GLP-1 agonism

Moreover, in attempts to replace the hydroxyl group of the tyrosine moiety to avoid potential problems with phase II metabolism compound 27 was prepared (Barlow et al., 2020)

Abstract Loss of sensory hair cells from exposure to certain licit drugs (e.g., aminoglycoside antibiotics, platinum-based chemotherapy agents) can result in permanent hearing loss