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Diminished gastric function in individuals with atrophic gastritis can result in bacterial overgrowth in the small intestine and cause food-bound vitamin B 12 malabsorption

The ideal pH window for GHK-Cu stability falls between 5.0 and 6.5, narrower than many other peptides tolerate

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[149] Derived from Table 2 available on [150] History [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy

They also have some differences in their structure, mechanism of action, and primary uses