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Rodrigues, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Cell 63 , 206217 (2016)

Beyond these, oxidative stress is also linked to memory loss and depression, highlighting the importance of oxidative balance for cognitive and mental health

Many of the beneficial and anti-aging effects of NAD + precursor administration could be due to NAD + acting as a signaling molecule to activate the mitochondrial unfolded protein response (UPR mt ) (Mouchiroud et al., 2013)

demonstrated that hypericin-mediated PDT (HY-PDT) induces ferroptosis in CCA cells by inhibiting the AKT/mTORC1/GPX4 axis, downregulating GPX4, decreasing GSH, and increasing ROS and lipid peroxidation products, while also suppressing proliferation, migration, and EMT

Research using animal murine models found that hexarelin treatment reduced brain damage by 39%