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Introduction The thioredoxin (Trx) system constitutes a pivotal intracellular antioxidant defense network that plays an essential role in maintaining cellular redox homeostasis and modulating signaling cascades, impacting numerous cellular processes such as proliferation, differentiation and apoptosis (13)

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The following sgRNAs for GGT1 CRISPRi were used: sgGGT1 1 (HL-ID: 3) forward: 5-CACCGGTGCCTCCCACTGTCCGCCG-3

RNA-Seq data statistics