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Eur Neurol 58:9699 Tyagi N et al (2005) Mechanisms of homocysteine-induced oxidative stress

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If the pain is associated with a change in bowel or bladder function, this may indicate cauda equina syndrome, in which the spinal cord is at risk of permanent damage, and emergency care should be accessed immediately

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The central mechanism in the vast majority of cases is a reduction in DAO enzyme activity or expression