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The data presented underscore some key components of hepatic nutrient-sensing pathways, particularly CRAT and SIRT3, in response to NQO1 transgenesis, which are responsible for attenuating diet-induced imbalance in glucose and lipid metabolism, cellular redox, oxidative stress, and mitochondrial dysfunction

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Several compounds from garlic , including ajoene (Hattori 2001), diallyl disulfide (Zhao 1998), S-allylmercaptocysteine (Sumioka 2001), and fresh garlic homogenates (Wang 1996) have been shown to preserve liver glutathione levels as well as reduce serum markers of liver damage, liver tissue death, and animal mortality in rodent models of acetaminophen overdose when supplied in sufficient quantities (up to 5 g/kg for fresh garlic homogenates)

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