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2019;144(5):1242-1253.e7

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Abbreviations NAFLD: Non-alcoholic fatty liver disease ER: Endoplasmic reticulum ROS: Reactive oxygen species NAC: N-acetylcysteine GSH: glutathione HF: high fat diet CD: chow diet PVDF: polyvinylidene difluoride ECHS1: Enoyl-CoA hydratase SREBP1: Sterol regulatory element-binding protein 1 UPR: unfolding protein response p-PERK: protein kinase RNA-like endoplasmic reticulum kinase phosphorylation ATF4: activating transcription factor 4 HSP: heat shock protein ClpP: Clp protease proteolytic subunit HIRI: hepatic ischemia-reperfusion injury JNK: c-Jun N-terminal kinase FAO: fatty acid -oxidation References Obesity: preventing and managing the global epidemic

The immune system will then produce excessive inflammatory chemicals and in some cases, auto-antibodies because it is in a hyper-stimulated state