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El subsitio S4 se forma entre el bucle que contiene los aminocidos 270-279 y 350-359 de la s Eq ID NO: 134 y contiene 3 dominios de unin a ligando: la "secuencia hidrfoba" (formada por los restos Tyr279, Phe356 y Trp399 de la SEQ ID NO: 134), el "orificio catinico" (formado por la cadena secundaria de Glu277 y la estructura principal de K276 de la SEQ ID NO: 134), y el sitio del agua (formado por los restos Thr278, Ile357, y Thr359 de la SEQ ID NO: 134) (Rai et al., Curr

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Recent advances in diabetic kidney diseases: from kidney injury to kidney fibrosis

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Neurobiological effects of the green tea constituent theanine and its potential role in the treatment of psychiatric and neurodegenerative disorders