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As a treatment for facial paralysis, especially synkinesis, BOTOX treats a variety of conditions, including: Excessive muscle tightness around the eye (blepharospasm) Excessive and constant facial muscle contraction (facial spasticity or hypertonicity) Involuntary facial movement (synkinesis), most commonly oral-ocular synkinesis, in which the eye closes when attempting to smile or eat or ocular-oral synkinesis, in which the mouth moves when attempting to close the eye

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Moreover, after crossing the blood-brain barrier in vivo, they struggle to effectively diffuse to distal pathological regions within the brain parenchyma, failing to meet the widespread demands of the dopaminergic axonal network