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In addition, chlorogenic acid could sensitize HCC HepG2 and Hep3B cells to 5-fluorouracil treatment by inhibiting the activation of ERK via increasing ROS production [271]

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[5] However, by 2005, it became clear that the biochemical assay consists of a fluorescent probe that interacts nonspecifically with resveratrol and that resveratrol is not a SIR2 activator [11] Despite the scientific debunking of resveratrol, Sinclair maintains an outspoken advocacy for resveratrol as an anti-aging drug and supplement