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High endemic areas are concentrated in western Siberia in the Ob River basin, including Khanty-Mansiysk Autonomous Okrug, Yamalo-Nenets Autonomous Okrug, Tyumen oblast, Tomsk oblast, Omsk oblast, and Novosibirsk oblast (49, 50)

Ouellette J, Toussay X, Comin CH, Costa LDF, Ho M, Lacalle-Aurioles M et al (2020) Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice

Drug Metab Dispos 2020;48:326-36

Metabolites 12 (7), 579

Resistance plasmid families in Enterobacteriaceae

For some local diseases related to the skin or nervous system, such as skin nerve injury, local neuropathy, etc., cream formulations can directly deliver drugs to the affected area, increase the concentration of drugs locally, and enhance the therapeutic effect