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Data were generated and/or analysed by the Proteomics Resource Center (RRID: SCR_017797), Electron Microscopy Resource Center, Bioinformatics Resource Center, Fisher Drug Discovery Resource Center and the Flow Cytometry Resource Center at The Rockefeller University

1907 (1557x 2 risk factors, 350x 1 risk factor) patients were invited for assessment of which 430 (22.5%) patients attended

Octyldodecanol is a fatty alcohol sourced from plant oils like coconut or palm (or made synthetically)

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Levels of the blood protein albumin, as it is lost in the urine, can also be reduced in certain types of kidney disease (Bolisetty 2011

The patients were given either CNM-Au8 or a placebo and alterations in motor neuron function and respiratory metrics were included as primary objectives, whilst biomarkers of neurodegeneration and quality of life evaluations were included as secondary outcomes