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(PubMed) Berginc K, Milisav I, Kristl A

Dose increase: at Day 16 inside the on phase, the dose steps from the low end to the high end of the range

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To synthesize these elements into a practical tool, Figure 5 summarizes a stepwise PKPD algorithm that starts from genotype-inferred metabolic capacity, explicitly accounts for phenoconversion, incorporates secondary pharmacodynamic markers, and uses TDM for continuous phenotype reassessment during antidepressant management

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