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Of the common proteins (839), there were 61 significantly downregulated proteins and 35 significantly upregulated proteins in the GF-HLCs compared to SM-HLCs (Figure 4B)

in the Journal of Pharmacology and Experimental Therapeutics (which established Dihexas HGF/c-Met mechanism via Morris water maze rescue with HGF antagonist blockade) was the subject of an Expression of Concern in 2021 and was formally retracted in April 2025 by the publishing journal following investigation into image manipulation

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However, the opposite has also been shown to be true: Theres evidencealthough primarily in animal studiesthat increasing NAD levels may slow aging