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263, 264, 265 Although -adrenergic blockers are not currently considered a first-line treatment for hypertension (except in those with coronary heart disease, heart failure, atrial fibrillation or other conditions helped by beta blocking agents), these agents, especially the vasodilating -blockers, 266 may also be useful in the obesityhypertension phenotype, particularly given their heightened sympathetic nervous system responses

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Building on these foundations, early-phase clinical trials in PCOS, endometriosis, and leiomyomas should prioritize subgroups with high oxidative, inflammatory, metabolic, or fibrotic burden

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Redox biology , 11 , 701-707