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Injecting in a fed state or evening window reduces fat oxidation efficiency by 3040% due to elevated insulin and circadian suppression of NAMPT activity

One important caveat

Simpsons colleague at Opt Health, agrees: Theyre mimicking what your body already does but with more specificity

This rides the GLP-1 arm, so it is light at the bottom of the ladder and stronger higher up

10.1369/jhc.6A7155.2007 88

Studies show this is because oral tablets are absorbed by the digestive system, causing the medication to be distributed slowly throughout the body, reducing its targeting ability and effectiveness