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However, the mechanisms underlying the synaptic and mitochondrial aberrations in FXS have yet to be established

The increased redox imbalance could result from oxidants in CS (Suzuki et al., 2008) and activated inflammatory cells (Boutten et al., 2010)

Toogood PL, Clauw DJ, Phadke S, Hoffman D

For example, an attenuated Salmonella typhimurium strain (named VNP20009) obtained by deletion of the purI and msbB genes not only dramatically improved safety, but also promoted their accumulation in the tumor tissue (Toso et al., 2002)

The recent application of FDA-approved intranasal drugs still indicates a trend toward treatments for acute conditions requiring rapid onset of action