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The dramatic clinical effect of COL5A1 haploinsufficiency is surprising, given that collagen V is a quite minor constituent of collagen in skin, tendon, and ligament, but the clinical phenotype clearly supports an important function for collagen V in the maintenance of biomechanical integrity of collagenous matrix

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4a, the G/D-CuP group exhibited the most intense CD206-associated red fluorescence signal among all treatment groups, indicating that G/D-CuP promotes macrophage polarization toward the M2 phenotype

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So while its proprietary TriHex peptide technology is all about stimulating collagen and elastin so new skin cells can literally live their best lives, the ceramides in the formula function as a safeguard, preventing it from being too aggressive, even on the dullest, driest skin