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Experimental models of depression have demonstrated a reduction in the number and density of GFAP-positive astrocytes in the prefrontal cortex (PFC), locus coeruleus, hippocampus, and amygdala, alongside changes in their morphology and functionality (Zhang et al., 2008

as a possible source of biomarkers (discussed in Section 5) for respiratory, neurological, and metabolic diseases as well as for cancer [182]

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doi:10.1016/j.tiv.2011.03.006 Chandrasekaran K, Swaminathan K, Kumar SM, Clemens DL, Dey A (2012) Increased oxidative stress and toxicity in ADH and CYP2E1 overexpressing human hepatoma VL-17A cells exposed to high glucose

doi: 10.1053/gast.2000.9370 151 MimuraTRizzelloFHelwigUPoggioliGSchreiberSTalbotICet al

This prompted researchers to discern a substantial genetic factor contributing to the condition