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EGCG is another major form of dietary polyphenol, and its combined use with EGFR-TKIs has been shown to significantly reverse the Warburg effect, leading to increased OXPHOS and ROS and overcoming drug resistance in non-small cell lung cancer [188]

To clarify the role of ROS in SQSTM1 mRNA increase, we first checked that preincubation with the ROS scavenger GSH (4 mM) or NAC (5 mM) diminished the ROS (data not shown), accompanied with a reversal of cell viability (CCK8), apoptotic phenotype (cleaved PARP) and integrated stress (p-p38) (Supplementary Figure S6b and S6c)

It wraps the nutrient in a phospholipid structure so the body can handle it more like something familiar

Kuscu, C

Y., and Kandil, R

doi: 10.1007/s12298-021-01057-4 61 HajianfarR.KolicsB.CernkI.WolfI.PolgrZ.TallerJ