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European Commission Communication and Information Resource Centre for Administrations

Trospium (1530 mg b.i.d.), which does not cross the bloodbrain barrier, as well as solifenacin (5 mg o.i.d), and darifenacin (7.515 mg o.i.d.), that selectively stimulate peripheral M3 muscarinic receptors, are less likely to cause cognitive side effects and may be therefore preferred [114, 232]