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Furthermore, genetic deletion of Gpx1 markedly exacerbates atherosclerosis in Apoe -/- mice (398,399), while overexpression of Gpx4 in Apoe -/- mice inhibits atherogenesis (400)

However, some animal studies did not observe any association between riboflavin status and antioxidant enzyme activity ( Reference Adelekan and Thurnham 38 , Reference Dutta, Seirafi and Halpin 39 )

Mechanistic Research Perspective Modulation of cellular signaling pathways Regulation of gene expression and epigenetic pathways Investigation of telomerase-associated signaling mechanisms Peptide-protein interaction studies in biochemical research Cellular communication and molecular pathway analysis Primary Research Applications Cellular and Molecular Biology Research: Used to investigate peptide-mediated signaling and regulatory pathways within experimental cell systems

12 and Supplementary Tables 315

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Salinity-induced ionic and osmotic instability results in increased generation of reactive oxygen species and methylglyoxal, leading to oxidative and carbonyl stress