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doi: 10.1080/2162402X.2017.1398877 39 MartinAMNirschlCJPolanczykMJBellWRNirschlTRHarris-BookmanSet al

Because specific vitamins and minerals work antagonistically to one another, consuming large amounts of isolated supplements like B1 (thiamine) can contribute to a deficiency in vitamin B6 over time

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For adults who tolerate 2.4 mg for at least four weeks and need additional weight reduction, the current label allows a maximum of 7.2 mg weekly

Notably, the E406G mutation, which disrupts a critical salt bridge for taurine binding, resulted in a complete loss of function, underscoring its essential role (Fig