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doi:10.1016/s0048-9697(01)00845-2

Recruitment and migration Neutrophil recruitment is initiated by alterations in the endothelial surface, which are stimulated by inflammatory mediators released by tissue-resident sentinel leukocytes on contact with pathogens

Persistent redness lasting more than two weeks warrants professional evaluation

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Pinch a fold of skin on the inner thigh, insert a 29 to 31 gauge insulin needle at a 45-degree angle, and inject slowly over 5 to 10 seconds