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doi: 10.1074/jbc.M707951200

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Similarly, section 1833(t)(8)(F) of the Act requires under the OPPS that in the case of a Part B rebatable drug (except for a drug that has no copayment applied under subparagraph (E) of such section or for which payment is packaged into the payment for a covered OPD service or group of services), in lieu of the calculation of the copayment amount that would otherwise apply under the OPPS, the provisions of section 1847A(i)(5) of the Act shall, as determined appropriate by the Secretary, apply in the same manner as the provisions of section 1847A(i)(5) of the Act apply under that section

Modified membrane and cell physiology, specifically modulation of sterol biosynthesis and membrane composition, further reduces susceptibility to drugs in biofilms

These next-generation agents represent a shift towards more targeted and potentially fewer toxic treatments, offering hope for improving clinical outcomes and overcoming the resistance encountered with earlier anti-angiogenic therapies