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Additionally, patients with more aggressive TCs (high risk PTC or ATC) exhibited high low-density lipoprotein (LDL) level, which might be attributed to the elevated expression of LDL receptors in TC cells

van Galen, P

It has been noted HDAC inhibitors as monotherapy were initially incorporated into the clinical exhibits limited effectiveness, acquisition of drug resistance as well as adverse effect in the treatment of cancer [101, 102]