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When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted

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9 Many women with PCOS have trouble becoming pregnant due to infrequent ovulation or lack of ovulation altogether, although there still may be menstrual bleeding (known as anovulatory cycling)

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This finding suggests that intranasal GSH may have some capacity to cross the BBB and increase CNS GSH levels