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Conceptual legacy: By linking mutagenesis, mitochondrial biology, and nutrition, Ames helped frame aging as a mechanistic, molecular process rather than an inevitable, mysterious decline

This article and associated images are based on a poster originally authored by Sivakumar, M, Smith, E, Shumate, J, Scampavia, L, Spicer, T, Hernandez, D and Peters, C and presented at ELRIG Drug Discovery 2025 in affiliation with BMG LABTECH and UF Scripps Institute

Of the 71 patients who developed GBN, 22.54% developed BN

Therefore, the acylcarnitines as biomarkers alone are not sufficient to predict APAP-induced hepatotoxicity, but can serve as complimentary biomarkers in combination with the current clinical markers