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Large quantities of intracellular ROS hyperproduction are believed to participate in a diverse scope of either nonmalignant or malignant diseases that affect the nervous, cardiovascular, and respiratory tract disorders, including chronic obstructive pulmonary disease, GIT (e.g., inflammatory bowel disease and irritable bowel syndrome), urogenital, reproductive, and metabolic systems [20, 24], besides mental and immune system disorders [25]

Key pathways for energy production closely related to migraine include the synthesis of adenosine triphosphate (ATP) through glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation (Figure 1)

They may help the body adapt to stress, help keep cortisol levels balanced, and can support better sleep and HPA axis function

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Batool, B

doi: 10.5056/jnm16114 8 BalamiJ