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As in previous studies 7,11 , non-immune cells like endothelial cells, FAPs and myonuclei were present following injury, but at transiently lower relative abundances

Additionally, improvements in glycemic control, inflammation, and psychological well-being associated with GLP-1 therapy might secondarily affect stress physiology without directly suppressing cortisol secretion

Future clinical studies should directly measure therapeutic plasma levels particularly for dobutamine during PS-DVB hemoadsorption and assess whether dosing adjustments are required to maintain intended inotropic effects without compromising safety