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Therefore, our findings suggest that pyroptosis of synovial macrophages plays a role in inducing inflammation in synovial chondrocytes and targeting synovial macrophages may be a potential therapeutic strategy for OA management

The recognition of many natural products, and some drugs that have been marketed or used in the clinic were found to have the effect of inhibiting System X c /GSH/GPX4 axis, thereby inducing ferroptosis

Based on the current knowledge, they are predominantly involved in the later stage of the disease

Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation

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