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Potential effects of curcumin on the activities of HDACs/HATs proved that curcumin is the most potent inhibitor of HDACs as presented in Table 1 (Liu et al., 2005

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doi: 10.1038/embor.2008.173

10.1016/S0140-6736(10)60484-9 8

The steady behavior of the functionally significant residues between the corresponding ligands and the protein is shown by the RMSF fluctuation plots (Fig 8a)