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Zinc also inhibits the differentiation of Th17 cells by interfering with the IL-6/STAT3 signaling pathway and preventing the phosphorylation of IL-1 receptor-associated kinase 4 [332]

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Of note, vitamin D can protect disc degeneration and increase TGF- and insulin -like growth factor - 1 (IGF-1) ( 9.3.2 Bioactive factors with carriers Although stem cell-based therapy combined with prolonged exposure to growth factor is considered a promising treatment, its effectiveness in alleviating IDD is limited by the short life of the growth factor