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2021;11(4) doi: 10.3390/biom11040521.521 [DOI] [PMC free article] [PubMed] [Google Scholar] 87.Halestrap A

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Whereas nearly all patients with type 1 diabetes are aware that they have the disease because of the effects of severe insulin deficiency, roughly 6.2 million people in the United States with the type 2 disease are currently unaware that they have diabetes (3, 17)

Consequently, we conducted an experiment on rats to simulate T2DM by providing them with a diet high in fat and administering a low dosage of streptozotocin, which replicates the effects of T2DM [47]

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