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View Abstract Towards precision medicine in clinical trials for the treatment of urologic chronic pelvic pain syndrome: lessons from the MAPP Research Network

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This excellent paper provides definitive evidence that the capacity of N -acetylcysteine to regulate drug-seeking behaviour results from actions on the cystineglutamate exchanger and is associated with preventing the large release of glutamate in the accumbens during drug seeking

Optimal Timing for Taking Vitamin B12 Supplements For individuals who require vitamin B12 supplementationwhether due to confirmed deficiency, dietary restrictions (such as veganism), or malabsorption conditions the timing of supplementation is generally flexible and should be guided by personal preference and tolerability rather than any specific metabolic advantage related to weight loss

4428-A PFOA EXPOSURE RESULTS IN SEX-DEPENDENT EFFECTS ON HEPATIC AND WHOLE-BODY LIPID HOMEOSTASIS THAT DIFFER BY PPARA STATUS Frederick Ekuban 1 , Greylin Nielsen 2 , Dibson Dibe Gondim 1 , Wendy Heiger-Bernays 2 , Thomas Webster 2 , Matthew Cave 1,3 and Jennifer Schlezinger 2 , (1)University of Louisville, Louisville, KY, (2)Boston University, (3)Robley Rex VAMC Background: Per- and polyfluoroalkyl substances (PFAS) are a large group of persistent chemicals that have been released pervasively in the environment leading to widespread exposure for human populations