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To the best of our knowledge this is the first report on measurement of GSH in PC-12 cells upon treatment with these reagents

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It seems likely that these observations in macrophages may well extend into the microglia 36 , their equivalent cells in the CNS

It protects cells by neutralizing free radicals and detoxifiing things like heavy metals, mold toxins, and other environmental carcinogens

Theranostics (2021) 11:883654

To address this knowledge gap, here we develop a mathematical model that incorporates the most essential molecular elements for NADPH production, ROS generation, GSH synthesis, and detoxification of ROS by GSH in the outer retina, formed by photoreceptors and the RPE (see Fig