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This is unknown, but ~12-24 hours may often be reasonable

The mean change of ALSFRS-R total score during the 12 months after baseline, in subjects treated with ALCAR 3 g/day and not treated subjects

2008 Nov;28(11):738-43

The prevalence of promiscuous equilibrative transporters of non-native substrates has significant implications for strain development in biotechnology and offers an explanation as to why transporter engineering has been a challenge in metabolic engineering

Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial

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