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Reactive oxygen species (ROS) are natural products of mitochondrial oxidative metabolism and oxidative protein folding

A section on computational modelling algorithms using information from crystal structures and ligands is included to inform readers about the use of in silico methods to gain information about transportersubstrate interactions

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Mutation of E 74 to glutamine (Q) also induced helical formation in the CHAC2 loop 2, suggesting it might be the catalytically relevant glutamate residue that alternates with E 83 (Nguyen et al., 2020)

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Because of its availability for clinical application, rhGH became and is now the drug of choice, not only because of its efficacy but also because it avoids the risk of transmitting fatal, slow viral (prion-mediated) Creuzfeldt Jacob Disease which was sometimes associated with the cadaver-derived hormone