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Beyond motor symptoms, PD is associated with a variety of non-motor symptoms such as dysautonomia (for example, constipation, orthostatic hypotension) 3,4,5,13 , sleep disturbances (for example, rapid-eye-movement-onset sleep disorder) 1 , and the slowing and diminishment of voluntary behaviour (for example, bradykinesia, abulia, apathy, executive dysfunction) 14

Cell Res 18 , 1726, (2008)

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Folkert, I, Mehran, RJ, Sun, R, Morris, VK, Overman, MJ, Kee, BK, Antonoff, MB , Tzeng, CW, Dasari, NV, Tran Cao, HS, Parseghian, C, Vilar Sanchez, E, Willis, JA, Newhook, TE, Hofstetter, WL, Kopetz, S, Vauthey, JN, Chun, YS

Garcia-Alonso, L