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Notably, chronic low-grade inflammation and dysfunction of visceral adipose tissue (VAT) are key drivers of obesity-related metabolic abnormalities, such as insulin resistance and type 2 diabetes

Approximately 5% of the inhaled O 2 is converted to reactive oxygen molecules with an unpaired number of electrons such as hydroxyl (OH), superoxide anion (O 2 -), hydrogen peroxide (H 2 O 2 ), oxygen singlet (O 2 ), hypochlorite (OCI-), nitric oxide (NO), and peroxynitrite (ONOO-) radicals

The NLRP3 inflammasome inhibitor MCC950 has shown promising results in preclinical studies

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Joint pain is not considered one of the most common tirzepatide side effects, but some people report achy joints, stiffness, muscle soreness, or body aches during treatment