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Therefore, to show the exact effects of CLA supplementation on physical performance, future studies are needed which account for potential confounding variables

However, the reverse Warburg effect does not apply to all tumors (221)

It is also a co-factor for GPX4-mediated lipid detoxification 35 , and GPX4 activity is necessary for the survival of several tissues, including the liver 36 and kidney 37

Namely, normoxia corresponds to metabolic homeostasis, OGD begins with a reserve mode using internal resources (OGD1), moving on to an extreme mode (OGD2) in case of energy depletion