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Children of mothers with iodine deficiency may have intellectual disabilities and problems with growth (stunted growth), hearing, and speech

The P2x7 receptor in infection and inflammation

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(c) mitochondria that degrade and/or sequester ROS

doi:10.1196/annals.1320.002

Implications for management and future directions The reclassification from variants of uncertain significance to either pathogenic or likely pathogenic in accordance with ACMG guidelines, establishing a definitive diagnosis for an individual, is important for appropriate management, predictive testing for other family members, and the availability of reproductive options such as preimplantation genetic diagnosis (PGD)