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The thiol group of C32 in PfGrx therefore facilitates the C29-dependent deglutathionylation of roGFP2(SSG) without forming an intramolecular disulfide bond

Int J Mol Sci 19:447

Such studies can enhance our understanding of lipid-dependent myelin homeostasis and reveal new therapeutic approaches for disease-related demyelination (Berghoff et al., 2022

Three key elements are needed to trigger the ferroptotic pathway: 1) Polyunsaturated long-chain fatty acids (PUFAs) stored in phospholipid membranes 2) Redox-active iron 3) A defective lipid peroxide repair system