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doi: 10.1016/j.abb.2014.08.017 55 MowersEESharifiMNMacleodKF

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"Cobalamin Deficiency: Clinical Picture and Radiological Findings"

GADD45 upregulates SIRT1 levels by inhibiting ubiquitinproteasome degradation To exclude the influence of protein synthesis on SIRT1 levels, and because SIRT1 can be regulated through ubiquitination, we further examined whether GADD45 affects SIRT1 stability