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It hasnt been tested directly in menopausal women, but early research and animal models raise intriguing questions worth exploring

167,210,211,212 Notably, in neointimal vascular smooth muscle cells (VSMCs) or in the intimal lesions of atherosclerotic vessels, the Cu chaperone ATOX1 and exporter ATP7A are found to be highly expressed and colocalized

Adverse effects are poorly documented due to limited human research

Figure 4: Percentage of Nissl-positive neurons in each of the four different experimental groups included in the first part of the study

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This size-based penetration advantage is central to its topical research applications and helps explain why laboratory studies have consistently demonstrated biological activity following topical application models